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This workshop is aimed at introducing early career bioscience researchers to the power ofsynchrotron based facilities. The focus isthe structure determination and other biophysical resources required for vaccine design, drug discovery, industrial enzymologyand agrochemicals. The course will trace the technology required to go from gene to protein structure, as well as synchrotron based techniques for imaging cells. Topics covered will include advanced strategies for crystallization, high-throughput data collection by X-ray diffraction, single particle cryo-EM, structure refinement, X-ray tomography, circular dichroism andspectroscopy. Participants will learn how to access synchrotron based resources and getpractical experience of working with proteins, data collection, data processing, structure interpretation and complex experimental strategies. Time has been reserved to collectyour own data using remote access of an MX beamline at the Diamond Light Source.
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